Chemical Biology of opioid receptors

Research in the Majumdar laboratory is aimed at attaining functional selectivity of opioid agonist action from its on target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches. Work from the laboratory has led to probes which display G-protein biased signaling, partial agonism, transmembrane splice variants of mu opioid receptor agonists and aided the crystallization of kappa opioid receptor in its active form.